Cystic Fibrosis: Discovery of CFTR Modulators

 April 20, 2017

How are modern day chemists seeking to treat cystic fibrosis? Join Peter Grootenhuis of Vertex Pharmaceuticals as he delivers a brief overview of the drug discovery approaches and challenges to identify small molecules CFTR modulators. These compounds improve the trafficking, processing and/or restore the function of the mutant CFTR protein and address the primary cause of cystic fibrosis.

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What You Will Learn

• How misfolded mutant CFTR is partially ‘fixable’ by a combination of complementary drugs
• Why an open mind is required when working with CFTR modulators
• Examples of multiple HTS campaigns and medicinal chemistry efforts using phenotypic assays and cultured primary human cells from CF patients were essential to the discovery of two CFTR modulator drugs

• Date: Thursday, April 20, 2017 @ 1 - 2pm CT
• Fee: Free to Attend
• Download Slides: Available Day of Broadcast